Variola virus infection causes smallpox, which is a highly contagious and often deadly disease that has plagued humans throughout history. Naturally occurring smallpox was eradicated by the early 1980s due to vaccination, and most Americans no longer received a smallpox vaccine after the early 1970s.
In this study, participants will receive an FDA-approved oral antiviral medication intended for the treatment of smallpox, or placebo. The goal of this study is to assess the tolerability of the medication when taken for a longer period than what is currently approved by the FDA.
No participants will be exposed to smallpox as part of this study — blood draws are taken to assess the medication’s effect.
Eligible participants…
- Must be a healthy adult between the ages of 18 and 80
- Will receive compensation for study-related time
- Do not need insurance to join this study
For more information, complete the form on this page. After you submit your information, a Meridian enrollment specialist will call you to talk about the study. There is no obligation to join — you can decide if the study is right for you.
You can also talk to a Meridian enrollment specialist about this study by calling (402) 934-7563.

Submit your information
Study Location
Meridian Clinical Research
3319 N 107th St
Omaha, NE 68134
Founded in 1999 in Omaha, NE, Meridian studies the safety and effectiveness of new medicines, devices, and treatments. Its mission is to enrich lives by providing quality, compassionate care to patients and unparalleled clinical research services. Clinical studies help scientists develop life-changing medicines, but it starts with you — participation makes it all possible. For more than 20 years, thousands of patients have trusted Meridian because of our focus on creating a positive patient experience.
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